Malignant melanoma and melanocortin 1 receptor

A 99mTc-tricine-HYNIC-labeled Peptide Targeting the Melanocortin-1 Receptor for Melanoma Imaging

Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target for the development of α-MSH peptide based imaging and therapeutic agents. In this work a new lactam bridge α-MSH analogue was synthesized and radiolabeled with 99mTc via HYNIC chelator and tricine as co-ligand. Also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

A 99mTc-tricine-HYNIC-labeled Peptide Targeting the Melanocortin-1 Receptor for Melanoma Imaging

Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target for the development of α-MSH peptide based imaging and therapeutic agents. In this work a new lactam bridge α-MSH analogue was synthesized and radiolabeled with 99mTc via HYNIC chelator and tricine as co-ligand. Also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

Skin type, melanoma, and melanocortin 1 receptor variants.

a 99mtc-tricine-hynic-labeled peptide targeting the melanocortin-1 receptor for melanoma imaging

melanocortin-1 (mc1) receptor is an attractive melanoma-specific target for the development of α-msh peptide based imaging and therapeutic agents. in this work a new lactam bridge α-msh analogue was synthesized and radiolabeled with 99mtc via hynic chelator and tricine as co-ligand. also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy.

PURPOSE Uveal melanoma is the most common primary malignant ocular cancer in adults. This tumor has a distinct expression pattern of markers compared with cutaneous melanoma. MC1R is under study as a potential target for antitumor immunity. Because of the potential immunogenicity of MC1R, it is important to evaluate its expression on uveal melanomas. METHODS Two novel monoclonal antibodies (M...